Estimates of the Hazard Ratio and associated 95% CI in the HEMO trial.

Cox: Cox proportional hazards model analysis, GL7-GL20: estimates produced by a Poisson GAM using 7, 10 or 20 nodes for the numerical integration of the cumulative hazard function. ICED: Index of Coexistent Disease, Alb: albumin. Analyses were stratified by study center, which implies that the Cox model used a separate baseline hazard for each participating center, while GAM models incorporated explicit interactions between study center and observation time. Variables used to adjust estimates were prespecified in the HEMO analysis protocol.Estimates of the Hazard Ratio and associated 95% CI in the HEMO trial.