RNA-seq of Runx3 cKO SFZ/DZ chondrocytes.
收藏Alliance of Genome Resources2026-08-01 收录
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Purpose: To demonstrate Runx3's association with organizing the extracellular matrix in SFZ/DZ chondrocytes. Method: RNA samples were collected from SFZ/DZ chondrocytes of 5-day-old Col2a1-Cre;Runx3fl/fl and Runx3fl/fl mice. Results: 18 genes were up- or down-regulated by more than 2-fold in the Runx3 knockout in SFZ. Conclusions: However, genes organizing the extracellular matrix were down-regulated in Runx3 cKO DZ chondrocytes. SFZ chondrocytes mRNA profiles of 5-day old Cntl and Runx3 cKO mice.
