LMNA mice model

Dilated cardiomyopathy caused by variants in the LMNA gene leads to malignant arrhythmogenic events, faster phenotype progression, and a high risk of sudden cardiac death. The murine model used in our study (LMNA-R249W) carries the widely reported pathogenic variant p.Arg249Trp (p.R249W, c.745C>T, rs121912496) in the LMNA gene, which is the most prevalent in LMNA-related congenital muscular dystrophy (L-CMD). This study explores the expression of miRNA and genes in the LMNA-R249W mouse model at 30 and 50 weeks of age. The expression of miRNA and genes from cardiac tissue and circulating RNA was analyzed through sequencing.