Zinc Uptake and Storage During the Formation of the Cerebral Cortex in Mice. Zinc Uptake and Storage During the Formation of the Cerebral Cortex in Mice

The aim of this work was to analyse the transcriptome of the mice cerebral cortex (or neocortex) during embryogenesis and at post-natal age. This complete transcriptomic analysis was dedicated to the analysis of the genes participating in the homeostasis of Zinc during brain development and formation. Our study represents a detailed analysis of transcriptomes during formation and dvelopment of the brain cortex, with biologic triplicates, generated by RNA-seq technology. This will provide a framework for comparative investigations of expression profiles. Our work offers an accurate quantitative and qualitative evaluation of mRNA content during mice embryogenesis. Overall design: Total mRNA from cerebral cortices of C57Bl6/J mice were generated in triplicate. Tissues were collected at embryonic days 11 (E11), E13, E17 and on post-natal day 1 pups.