Expression data from GNMT knockout mice cerebral cortex

We report that Gnmt-/- mice have abnormal behavior including spontaneous locomotion activity, PPI, TST and FST. Microarray analysis showed that genes expression profiles in male Gnmt -/- mice Keywords: Gnmt knockout Cerebral cortex tissues from wild-type or Gnmt knockout mice were used for RNA extraction and hybridization on Affymetrix microarrays. For 4 weeks old mice, total RNA were mixed in equal proportion from 3 mice.本研究报道，Gnmt基因敲除（Gnmt knockout）小鼠存在多项异常行为，包括自发活动、前脉冲抑制（PPI，Prepulse Inhibition）、悬尾实验（TST，Tail Suspension Test）与强迫游泳实验（FST，Forced Swim Test）相关表型异常。基因芯片分析显示，雄性Gnmt基因敲除小鼠的基因表达谱存在显著改变。 关键词：Gnmt基因敲除 本研究以野生型或Gnmt基因敲除小鼠的大脑皮层组织为实验材料，进行RNA提取并在Affymetrix基因芯片上完成杂交。对于4周龄小鼠，将3只个体的总RNA按等比例混合后使用。