Incidence of adverse reactions in general population treated with benzathine penicillin: individual and pooled results, 1954–2012.

Notes:*Only severe adverse reaction was reported.†Probable cases.‡These cases are included in the previous data (one penicillin prescription).§Data obtained from contact with corresponding author.||The study reported 16 events of Jarisch-Herxheimer reaction, but we did not consider them as adverse events.¶For the polled result only the incidence of adverse reaction with one prescription of penicillin was considered for Apter 2004 [95] study.