Loss of Fatty Acid Degradation by Astrocytic Mitochondria Triggers Neuroinflammation and Neurodegeneration

To investigate the role of astrocytic mitochondrial function in regulating brain function, we depleted the Tfam gene specifically in astrocytes of mouse brains (TfamAKO). Gene expression profiling analysis was performed using data obtained from the RNA-seq of the hippocampus of WT and TfamAKO mice. Comparative gene expression profiling analysis of RNA-seq data generated from five WT and five TfamAKO mice at 6-month-of-age.