B-Raf wild-type kinase domain in complex with a purinylpyridinylamino-based inhibitor
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B-Raf wild-type kinase domain in complex with a purinylpyridinylamino-based inhibitor Descriptor: 6-[2-[[3-(dimethylsulfamoylamino)-2,6-bis(fluoranyl)phenyl]amino]pyridin-3-yl]-7~{H}-purine, Serine/threonine-protein kinase B-raf Authors: Whittington, D.A, Epstein, L.F. Deposit date: 2015-12-15 Release date: 2016-05-04 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Purinylpyridinylamino-based DFG-in/ alpha C-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling. Bioorg.Med.Chem., 24, 2016
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2015-12-15
