<i>L</i><sub>0</sub> (expressed as <i>n</i> ⋅ <i>K</i><sub><i>d</i></sub> and <i>n</i> ⋅ <i>K</i><sub><i>d</i></sub>′) for a set of hypothetical hERG blockers resulting in the pro-arrhythmic fractional channel occupancy levels predicted from our AP simulations.
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Blocker Kd = 5 μM in all cases, where kon ranges between 1x104 and 1x109 M-1 s-1 and koff between 0.005 and 5,000 (noting that the pro-arrhythmic occupancy level increases as koff speeds). n ⋅ Kd was back-calculated from the predicted pro-arrhythmic occupancy using Eq 19.
创建时间：
2018-11-01
