Skin, gut, and sand metagenomic data tables on placebo-controlled sandbox biodiversity intervention study

The metagenomic data are related to the published research of “A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children” and Data in Brief article "Skin, gut, and sand metagenomic data on placebo-controlled sandbox biodiversity intervention study". This database contains 16S ribosomal RNA (rRNA) metagenomics of sandbox sand and skin and gut microbiota of children in the intervention and placebo daycares. In intervention daycares, children aged 3–5 years were exposed to playground sand enriched with microbially diverse soil. In placebo daycares, children were exposed to visually similar as in intervention daycares, but microbially poor sand colored with peat. Sand, skin and gut metagenomics were analyzed at baseline and after 14 and 28 days of intervention by high throughput sequencing of bacterial 16S rRNA gene on the Illumina MiSeq platform. We herein report the richness, diversity, relative abundance (Table 1) and community composition (Table 2) of sand bacteria between enriched intervention and placebo sandbox sand, and bacterial relative abundance shifts on the skin (Table 3) and in the gut between intervention and placebo groups (Table 4 and 5).