sIL-2RA concentrations in the sera of healthy controls and MS cases and plasma samples of T1D subjects.

Analyses of log10-transformed sIL-2RA concentrations of healthy control, MS and T1D datasets. The analysis of sIL-2RA levels for rs41295061 and rs11594656 in up to 1,257 T1D cases presents a subset of a previously published data set [8]. Analyses were performed using a 2-degree of freedom test. We note that the healthy control and MS case collection present random population samples, but that individuals from the T1D case collection were chosen based on their genotype at both rs41295061 and rs11594656 to achieve representation of all genotypes for both SNPs [8]. This selection allowed the study of the correlation between sIL-2RA levels and the relatively rare minor allele at rs41295061, currently the most strongly associated T1D SNP (MAF = 0.09). N, number of samples.
*T1D analyses were adjusted for covariates associated with log10-transformed sIL-2RA concentrations (Table S13).