Ultrasensitive129XeMagneticResonanceImaging:From ClinicalMonitoringtoMolecularSensing
收藏中国科学院兰州化学物理研究所科学数据中心2026-01-13 更新2026-01-17 收录
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资源简介：
Magneticresonanceimaging(MRI)isacornerstonetechnologyinclinical
diagnosticsandinvivoresearch,offeringunparalleledvisualization
capabilities.Despitesignificantadvancementsinthepastcentury,traditional
1HMRIstillfacessensitivitylimitationsthathinderitsfurtherdevelopment.
Toovercomethischallenge,hyperpolarizationmethodshavebeenintroduced,
disruptingthethermalequilibriumofnuclearspinsandleadingtoan
increasedproportionofhyperpolarizedspins,therebyenhancingsensitivityby
hundredstotensofthousandsoftimes.Amongthesemethods,
hyperpolarized(HP)129XeMRI,alsoknownasultrasensitive129XeMRI,
standsoutforachievingthehighestpolarizationenhancementandhas
recentlyreceivedclinicalapproval.Iteffectivelytacklesthechallengeofweak
MRIsignalsfromlowprotondensityinthelungs.HP129XeMRIisvaluable
forassessingstructuralandfunctionalchangesinlungphysiologyduring
pulmonarydiseaseprogression,trackingcells,anddetectingtargetmolecules
atpico-molarconcentrations.Thisreviewsummarizesrecentdevelopmentsin
HP129XeMRI,includingitsphysicalprinciples,manufacturingmethods,in
vivocharacteristics,anddiverseapplicationsinbiomedical,chemical,and
materialsciences.Inaddition,itcarefullydiscussespotentialtechnical
improvementsandfutureprospectsforenhancingitsutilityinthesefields,
furtherestablishingHP129XeMRI’simportanceinadvancingmedical
imagingandresearch.
提供机构：
中国科学院兰州化学物理研究所科学数据中心
创建时间：
2026-01-13
