Comparison of five models of the relationship between diclofenac concentration in a specified tissue and the concentration in liver from the same animal.

The parameters a, k and v (see text) are either assumed to vary among tissues (T) or to have a common value across all four tissues (C). In Model E the parameter k is set to the value 1 for all tissues. The residual deviance, number of fitted parameters and Akaike Information Criterion (AIC) are shown for each model. Models with the lowest AIC have reasonable fit without requiring the estimation of many parameters.