GeoMX spatial transcriptomic on biphasic Malignant Pleural Mesothelioma. GeoMX spatial transcriptomic on biphasic Malignant Pleural Mesothelioma

We applied a spatially resolved, high-dimensional transcriptomic approach to study MPM morpho-logical evolution. 139 regions across 8 biphasic MPMs (B-MPMs) were profiled using the GeoMx™Digital Spatial Profiler and Cancer Transcriptome Atlas to compare epithelioid and sarcomatoid components transcriptional profile and reconstruct the positional context of transcriptional activities and the spatial topology of MPM cells interactions.