Dataset from A Phase 1, Open-Label Study to Evaluate the Absorption, Metabolism, and Excretion of [14C]-BIIB074 in Healthy Male Subjects

The primary objectives of the study are: To determine the mass balance and routes of
elimination of BIIB074 and its known metabolites following administration of a single oral
dose of BIIB074 in healthy male participants and To describe the pharmacokinetics (PK) of
BIIB074 and its known metabolites and the disposition profiles of total radioactivity in
whole blood and plasma following a single oral dose. The secondary objectives of this study
are: To assess the safety and tolerability of BIIB074 in healthy participants and To identify
and characterize any additional metabolites of BIIB074 in plasma, urine, and feces.