Haplotype effects derived from the rs317657 and rs11177644 at the 12q15 locus in the Gutenberg Health Study (N = 1,467).

(1)Haplotype effects were estimated assuming haplotype additive effects after adjusting for age, gender, and LYZ and YEATS4 expressions when appropriate.(2)After adjusting for rs317657, the rs11177644-G allele was associated with decreased YEATS4 expression (β = −0.262, p = 1.36 10−138). After adjusting for rs11177644, the rs317657-T allele was no longer associated with YEATS4 expression (β = −0.003, p = 0.748).(3)After adjusting for rs317657, the rs11177644-G allele was associated with decreased LYZ expression (β = −0.208, p = 9.56 10−84). After adjusting for rs11177644, the rs317657-T allele was associated with decreased LYZ expression (β = −0.072, p = 1.24 10−10).