A new Co(II) coordination polymer: crystal structure and treatment activity on viral myocarditis by reducing CVB3 virus burdens
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This work presents the synthesis and characterization of a thiocyanato linked Co(II) coordination polymer [Co<sub>2</sub>L<sub>1</sub>(μ1,3-SCN)(η1SCN)]<sub>n</sub> (<b>1</b>) using potential multisite compartmental N,O donor Schiff base blocker ligand [N, N′-bis(3-methoxysalicylidenimino)-1,3-daminopropane] (H<sub>2</sub>L<sub>1</sub>) in presence of Co(OAc)<sub>2</sub> and KSCN. The structural determination shows that complex <b>1</b> shows a 1D chain-like structure composed of binuclear {Co2} cluster-based unit. Furthermore, the nanoparticles of complex <b>1</b> were prepared by a green grinding approach, which has good water dispersibility. In addition, for nano <b>1</b>, the treatment on the myocarditis induced by CVB3 virus was evaluated, and the mechanism was also discussed. Finally, the potential binding mode of the compound binding to VP1 indicated a potential binding site and regulation mechanism.
