Human PRMT5:MEP50 structure with Fragment 4 and MTA Bound

Human PRMT5:MEP50 structure with Fragment 4 and MTA Bound Descriptor: 4-methyl-1,5-naphthyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... Authors: Gunn, R.J, Lawson, J.D, Smith, C.R. Deposit date: 2022-05-06 Release date: 2022-10-05 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022