Data from: Effect of H. pylori infection on cytokine profiles and oxidative balance in subjects with chronic alcohol ingestion

Different amounts of ingested alcohol can have distinct effects on the
human body. However, there is limited research on chronic alcohol
consumption with Helicobacter pylori infection. We sought to investigate
the relationship between the cytokine profile, oxidative balance and H.
pylori infection in subjects with chronic alcohol consumption. A total of
142 subjects were divided into three groups: 59 subjects with chronic
alcohol ingestion and H. pylori infection (group A); 53 subjects with
chronic alcohol ingestion without H. pylori infection (group B); and 30
control subjects (group C). The serum levels of CagA, interleukin (IL)-10,
E-selectin, TNF-α, malondialdehyde (MDA) and superoxide dismutase (SOD)
activity were measured by enzyme-linked immunosorbent assay (ELISA). We
found that the ages and serum H. pylori CagA levels among the three
groups, as well as both the mean drinking age and the mean daily alcohol
consumption between groups A and B, were matched and comparable. Comparing
the BMIs among the three groups, the BMI differences were found to be
statistically significant (F=3.921, P<0.05). Compared with group C,
the BMIs in groups A and B were significantly higher (P<0.001 and
P<0.01, respectively); however, the BMI differences between group A
and group B were not statistically significant (P>0.05).
Additionally, no differences in the serum CagA levels were found in
comparisons among the groups (all P>0.05). The serum IL-10 and
E-selectin levels in group A were significantly lower than those in group
B (serum IL-10: P<0.05; E-selectin: P<0.05). The serum IL-10
in group A was significantly higher than that in group C (P<0.01);
the serum E-selectin levels in group A did not significantly differ
compared with those in group C (P>0.05). Furthermore, the serum
IL-10 and E-selectin levels in group B were significantly higher than
those in group C (serum IL-10: P<0.001; E-selectin: P<0.05);
however, the serum TNF-α levels did not differ among groups (all
P>0.05). Although the serum levels of MDA and SOD in groups A and B
were slightly lower than those in group C, there were no significant
differences among groups (all P>0.05). In conclusion, we believe
that H. pylori infection might cause a significant inhibition of certain
cytokine profiles in subjects with chronic alcohol ingestion. Moreover,
chronically ingested alcohol may exert an adjusted inflammatory effect,
but there was no association between H. pylori infection, chronic alcohol
consumption and oxidative balance.