Extracellular Vesicles Derived from Inflammatory Cardiomyocytes Mediate Macrophage Polarization and Alleviate Myocarditis via p38 MAPK Pathway

EVs derived from lipopolysaccharide (LPS)-stimulated cardiomyocytes (EVLPS) exhibit anti-inflammatory effects on macrophages and reduce cardiac inflammation in mice.To investigate gene expression changes induced by EVLPS treatment in inflammatory RAW264.7 using next-generation sequencing,we performed RNAseq. Overall design: mRNA profiles of LPS-stimulated RAW264.7 treated with either EVLPS or PBS were generated by deep sequencing, in quadruplicate