Phosphatidylinositol 3-kinase modulation of trophoblast cell differentiation

Alliance of Genome Resources2026-08-01 收录

滋养层细胞分化

PI3K信号通路

数据链接：

https://www.ncbi.nlm.nih.gov/gds/?term=GSE21938 数据链接链接失效反馈

官方服务：

资源简介：

Microarray analysis of stem, differentiated and differentiated Rcho-1 trophoblast stem cells treated with the PI3K inhibitor LY294002.

A Patient specific iPSC-based model of Hydatidiform mole reveals abnormal BMP4 signaling caused by NLRP7 deficiency. A Patient specific iPSC-based model of Hydatidiform mole reveals abnormal BMP4 signaling caused by NLRP7 deficiency

葡萄胎病理机制

滋养层细胞分化

Complete Hydatidiform Mole (HM) is a gestational trophoblastic disease resulting in hyper proliferation of trophoblast cells and absence of embryo development. Mutations in NLRP7 gene is a major cause

NIAID Data Ecosystem50

Trophoblast stem cells (TSC) global transcriptome in stemness and differentiation conditions after treatment with PF1-3. Mus musculus

滋养层细胞分化

溴结构域抑制剂效应

Here we report a potent, acetyl-lysine competitive and cell active inhibitor, PFI-3, that tightly binds to the bromodomain present in BRG1/BRM and the fifth bromodomain in Polybromo (BAF180). The high

NIAID Data Ecosystem30

ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development

滋养层细胞分化

胎盘发育

Invasive trophoblast cells are critical to spiral artery remodeling in hemochorial placentation. Insufficient trophoblast invasion and vascular remodeling can lead to pregnancy disorders including pre

NIAID Data Ecosystem10

Trophoblast stem cells sense glucose-acetate metabolism via histone acetylation to regulate syncytialization

滋养层细胞分化

表观遗传调控

Our RNA-seq data were used to explore the effects of oxamate and acetate on trophoblast syncytialization. CUT&tag data is to explore the gene region bound by H4K16ac.

NIAID Data Ecosystem30

Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model.

滋养层细胞分化

干细胞模型

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem20