NIH Task A24/A43 Murine Chronic Infection Model

The generation of a robust and reproducible chronic pulmonary bacterial infection model in mice is a major requirement for the study of infectious airways disease pathogenesis and therapy in cystic fibrosis (CF). These genomes were sequenced as part of an NIH Task Order (A24, A24 Option 3, and A43 Base Period) which seeks to characterize clinical isolates of P. aeruginosa and S. aureus to identify strains with increased likelihood of establishing chronic lung infections.