Potential Therapeutic Agents and Associated Bioassay Data for COVID-19 and Related Human Coronavirus Infections

The
COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2,
has led to several million confirmed cases and hundreds of thousands
of deaths worldwide. To support the ongoing research and development
of COVID-19 therapeutics, this report provides an overview of protein
targets and corresponding potential drug candidates with bioassay
and structure–activity relationship data found in the scientific
literature and patents for COVID-19 or related virus infections. Highlighted
are several sets of small molecules and biologics that act on specific
targets, including 3CLpro, PLpro, RdRp, S-protein–ACE2 interaction,
helicase/NTPase, TMPRSS2, and furin, which are involved in the viral
life cycle or in other aspects of the disease pathophysiology. We
hope this report will be valuable to the ongoing drug repurposing
efforts and the discovery of new therapeutics with the potential for
treating COVID-19.