Additional file 4 of Exploring the ATN classification system using brain morphology

Additional file 4. Assessment of face validity of the ACH using selected ROIs and CSF-total-Tau. ROI based comparison of evidence for a monotonic volume decline over 24 sequences obtained by permutation of the ACH progression sequence. Braak stage volumes were obtained using aggregated Freesurfer ROI volumes. Other2: A-T-N- ➔ A+T+N- ➔ A+T-N- ➔ A+T+N+; Other3: A+T-N- ➔ A-T-N- ➔ A+T+N- ➔ A+T+N+. ACH VX%: Percentage of voxels with highest evidence for ACH sequence inside the ROI mask. Neurodegeneration (N) by CSF Total Tau.