Transcriptome and Metabolome Sequencing of Cashmere Goat Skin Tissue

This study aims to integrate transcriptomics and metabolomics to systematically analyze the molecular differences in the skin tissues between Perennial Long Wool Type (PT-LCG) and Seasonal Long Wool Type (ST-LCG) Liaoning cashmere goats, and to reveal the regulatory mechanisms underlying their differences in cashmere production performance. The research focuses on key molecular events during the catagen phase of the hair follicle cycle. By screening differentially expressed genes and metabolites, it seeks to identify key factors related to lipid metabolism, energy supply, extracellular matrix remodeling, and inflammatory signaling pathways, ultimately constructing a synergistic "metabolite-receptor-gene" regulatory network. This study provides new insights into the regulatory mechanisms of the hair follicle cycle in cashmere goats and offers potential targets for molecular breeding, holding significant theoretical and practical relevance for improving cashmere yield and quality.