CD74? Myeloid Cells across Brain Pathologies

In this study, we conducted a comprehensive analysis of single-cell RNA sequencing data from immune cells isolated from the brain tissue of mouse models of Alzheimer's disease (AD), multiple sclerosis (MS), and brain metastasis (BrM). Our findings reveal a shared transcriptional signature among CD74? myeloid cells across these conditions, indicating a conserved inflammatory response that may be amenable to therapeutic targeting. These results highlight the role of CD74? myeloid cells as a unifying component of the immune landscape in diverse neurological disorders and lay the groundwork for future investigations into targeted interventions aimed at mitigating these pathologies. Overall design: scRNA-seq from CD45+ immune cells isolated from brain tissue of mouse models for Alzheimer's Disease, Multiple Sclerosis, and Brain Metastasis.