NFS1 inhibition in mice
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP516549
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资源简介：
Iron-sulfur clusters (ISCs) are cell-essential cofactors present in ~60 proteins including subunits of OXPHOS complexes I-III, DNA polymerases, and iron-sensing proteins. Dysfunctions in ISC biosynthesis are associated with anemias, neurodegenerative disorders, and metabolic diseases.To assess consequences of acute Iron-Sulfur cluster (ISC) inhibition in a whole body setting, we developed a mouse model in which key ISC biosynthetic enzyme NFS1 can be acutely and reversibly suppressed.
创建时间：
2025-06-26
