Pseudoamaolide P, a 1,2:3,4:9,10:9,19-tetraseco-cycloartane triterpene spiroketal lactone from seeds of <i>Pseudolarix amabilis</i>

A 1,2:3,4:9,10:9,19-tetraseco-cycloartane triterpene spiroketal lactone, pseudoamaolide P (<b>1</b>), two new labdane-type diterpenoids, pseudoamains A and B (<b>2-3</b>), and four known cembrane-type diterpenoids (<b>4–7</b>) were isolated from the seeds of <i>Pseudolarix amabilis</i>. The structures of these compounds were elucidated by spectroscopic analyses, including HRESIMS, 1D-, and 2D-NMR. The anti-inflammatory activities of the compounds were evaluated by suppressing the transcription of the NF-κB-dependent reporter gene in LPS-induced 293 T/NF-κB-luc cells. All compounds do not show potent activity.