Human umbilical cordÂderived mesenchymal stem cells (UCÂMSCs) induce a global transcriptional reprogramming in cisplatinÂdamaged human renal proximal tubular epithelial cells (RPTECs).
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
To gain insights into the genes involved in the protective effect of human umbilical cordÂderived mesenchymal stem cells (UCÂMSCs) on cisplatinÂinjured human renal proximal tubular epithelial cells (RPTECs), we performed a genomeÂwide differential gene expression analysis by Ion AmpliSeqTM Transcriptome sequencing that targets more than 20,000 human genes. Our data indicated that genes involved in the pathways related to mitochondria and energy homeostasis were strongly upregulated by stem cell treatment in respect to cells treated with cisplatin alone, possibly representing a de novo regenerative response induced by UCÂMSCs.
提供机构：
IRCCS â Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy
创建时间：
2022-02-20
