Data and code for: Benchmarking a gene expression signature against clinical and molecular features of clear cell renal cell carcinoma

Reproducibility materials for a retrospective benchmark of a fixed 18-gene expression signature in clear cell renal cell carcinoma. The release contains a checksum-verified public-processed-input reconstruction workflow, frozen definitions, pinned dependencies, aggregate model results, minimal plotting values and retrospective evidence for the original 102-gene candidate panel. Public sources include TCGA-KIRC, GSE53757, E-MTAB-1980 and GSE159115. GSE53757 contributed to feature selection. The study does not establish independent clinical utility or direct R-loop measurement. The gene evidence ledger includes unresolved and indirect support; non-estimable model terms and source-version limitations are retained. Raw sequencing, source matrices and complete clinical/cell working tables are not redistributed. Scripts download source resources from their original providers. The source ledger preserves third-party attribution. Fig 3B pairing labels and S1 rank/residual coordinates are minimized derived plot values, not guaranteed anonymous records.Unpublished draft: licenses and final public release remain subject to author confirmation. The uploaded ZIP is a local release candidate and will be finalized before publication.