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3T3 and E14 specific R-loops were generated by extracting mutually exclusive DRIP-seq peaks in both cell lines.
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2023-11-17
相关数据集
Two Distinct Types of RNA:DNA Hybrids Revealed by Evaluating Divergent “R-loop” Profiles Detected with Different Mapping Strategies
R-loop, a three-stranded nucleic acid structure, has been recognized to play pivotal roles in critical physiological and pathological processes. Multiple technologies have been developed to profile R-
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K562 R-loop peaks
The R package nucleR was used to first smooth DRIP-seq signal using filterFFT function (pcKeepComp = 0.05) and then to extract peaks using peakDetection (threshold = 95%). Finally, overlapping peaks w
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Genome-wide mapping of native G-loops in living cells
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HEK293 R-loop peaks
The R package nucleR was used to first smooth DRIP-seq signal using filterFFT function (pcKeepComp = 0.05) and then to extract peaks using peakDetection (threshold = 95%). Finally, overlapping peaks w
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spKAS-seq reveals R-loop dynamics using low-input materials by detecting single-stranded DNA with strand specificity. spKAS-seq reveals R-loop dynamics using low-input materials by detecting single-stranded DNA with strand specificity
R-loops impact transcription and genome stability and are related to human diseases. Genome-wide R-loop mapping typically uses the S9.6 antibody or inactive RNase H, both requiring a large number of c
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