Viral integration transforms chromatin to drive oncogenesis

We report that the integration of the human papillomavirus into the host genome increases chromatin accessibility, transcription, and CTCF binding within 100 kbp of the integration site which promotes oncogenesis in some patients. We used 5 patient-derived HPV16-positive cell lines. Three biological replicates for CTCF ChIP-seq, 1 lane of sequencing for ATAC-seq of each sample, and 4 lanes of sequencing for RNA-seq of each sample.