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Direct Targets of pSTAT5 signalling in erythropoiesis. Mus musculus

NIAID Data Ecosystem2026-03-10 收录

红细胞生成信号通路

STAT3转录调控

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA369275 数据链接链接失效反馈

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资源简介：

Identification of direct transcriptional targets of EPO-JAK2-STAT5 signalling in erythroid cells Overall design: ChIP-seq and 4sU-labelled RNA-seq following EPO treatment of J2E cells

应用场景：

创建时间：

2017-01-30

三阴性乳腺癌

STAT3转录调控

Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the tumor-originating cells are luminal or basal epithelial cells. Breast cancers arising from the lumi

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STAT5 is insufficient to drive steroid resistance in T-cell acute lymphoblastic leukemia despite activation of BCL2 and BCLXL upon glucocorticoid treatment

T-ALL类固醇抵抗机制

STAT3转录调控

Overexpression of STAT5B_N642H mutant results in the ligand-independent activation of STAT5 signaling and STAT5 transcriptional activity, without affecting MAPK-ERK or PI3K-AKT signalling pathways. Ov

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CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci

IL-6信号通路

STAT3转录调控

Cytokines are highly pleiotropic ligands that critically contribute to a balanced immune response. We have an incomplete understanding of how cytokines elicit their functional pleiotropy, which has li

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ChIP-sequencing of STAT3 in Zdhhc5 knockout oligodendrocytes

髓鞘形成分子机制

STAT3转录调控

Myelin sheath is an important structure to maintain normal functions of the nerves in central nervous system. Protein palmitoylation has been established as a sorting determinant for the transport of

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Targeting STAT3-FoxO1 axis reverses de novo and acquired PARP inhibitor resistance independent of BRCA status [ChIP-seq]

PARP抑制剂耐药机制

STAT3转录调控

PARP inhibition has been approved as a compelling strategy for treating multiple human cancers bearing homologous recombination defects (HRD). However, due to the lack of functional biomarkers of PARP

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Direct Targets of pSTAT5 signalling in erythropoiesis. Mus musculus

资源简介：

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