Candida albicans isolates from an oropharyngeal Candidiasis (OPC) model

Mice were infected with C. albicans strain AF485 using an oropharyngeal Candidiasis (OPC) model and single colony isolates were recovered from the tongue tissue of mice after 5 days. Three strains with specific single chromosome aneuploidies and AF485 were subjected to a second round of OPC and again multiple single colony isolates were recovered as described above. AF485 and single colony isolates from the 1st and 2nd OPC were subjected to whole genome sequencing.