Transcriptome profiling of Oncorhynchus mykiss infected with Low or Highly Pathogenic viral hemorrhagic septicemia virus (VHSV)

The rainbow trout (Oncorhynchus mykiss) is the most important produced specie in freshwater within the European Union, usually reared in intensive farming systems. The rainbow trout is highly susceptible to the viral haemorrhagic septicemia (VHS), a severe systemic disease widespread all over the world. Viral haemorrhagic septicemia virus (VHSV) is the etiological agent of the illness. Three classes of VHSV virulence (high, moderate and low) have recently been proposed based on the mortality rate caused on the viral strain sequence.The molecular mechanisms that regulate VHSV virulence and the stimulated gene responses in the host during infection are not completely understood. While some preliminary transcriptomic work has been reported in other species, no publications are known to date in rainbow trout. Herein we report the first time-course RNA-seq analysis on rainbow trout juveniles experimentally infected with a highly or low VHSV virulence.