Raudales_Cell Rep_RNA-seq data_Figure 4.xlsx

The following RNAseq data set pertains to Raudales et al. Figure 4F-I. (F) Dot plot for gene enrichment analysis shows top 10 GO terms (for genes up and down regulated) in each category after Notch1 knockdown. BP: biological processes, CC: cellular component, MF: molecular function.(G) Dot plot shows KEGG classification for differentially expressed genes (top 20 most significantly affected functions) following Notch1 knockdown. (H) Volcano plot shows gene expression based on log2 fold change and statistical significance (adjusted p<0.05, FDR). Gene names are attached to the top 10 genes most significantly up (orange) or down (blue) regulated. (I) Heat map shows top 30 differentially expressed genes in endothelial cells across each mouse in Notch 1 knockdown or wildtype control groups (n=6 mice per group). RNAseq data in F-H compare endothelial specific knockdown of Notch1 (n=6 mice infected with AAV-BR1-iCre) to wildtype control endothelial cells (n=6 mice infected with AAV-BR1-eGFP).