Main characteristics of the eligible studies sorted by 5 different serum biomarkers.

Note: ELISA* = Enzyme-linked immunosorbent assay; TP* = true positives, FP* = false positives, FN* = false negatives, TN* = true negatives; Abs* = Antibody.Assay method*：ELISA or ELISA+western = 1; other = 0; unknown = 2.Formula 1*: normal+2SDFormula 2*: P53 control protein ratio >1.3Formula 3*: density>1030Formula 4*: optical density>0.11Formula 5*: manufacturer’s formulaFormula 6*: the differences in the absorption values between the positive walls and controls was greater than 0.5Formula 7*: differences higher than 0.15 were scored positiveFormula 8*: index≥1.1,Absorption> = 1.6Formula 9*: ≥2.3-times of controlFormula 10*: mean+3SDNote: Sample collection time*: before diagnosis = 1; before treatment = 0; unknown = 2.Main characteristics of the eligible studies sorted by 5 different serum biomarkers.