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An Efficient Synthesis of Hydantoins via Sustainable Integration of Coupled Domino Processes

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NIAID Data Ecosystem2026-03-06 收录
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A highly efficient synthesis of hydantoins has been developed from simple and commercially available 1,3-dicarbonyl compounds, ureas, and methyl ketones or terminal aryl alkenes. This protocol involves a sustainable integration of two coupled domino processes: iodine-promoted synthesis of unsymmetrical 1,4-enediones (domino I) and the sequential transformation into hydantoins (domino II).

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2016-02-24
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