A Multiscale Electro-Metabolic Model of a Rat Neocortical Circuit Reveals the Impact of Ageing on Central Cortical Layers

Model Description and Data Availability

A full description of the model is available in the manuscript:

"A Multiscale Electro-Metabolic Model of a Rat Neocortical Circuit Reveals the Impact of Ageing on Central Cortical Layers"by Sofia Farina, Alessandro Cattabiani, Darshan Mandge, Polina Shichkova, James B. Isbister, Jean Jacquemier, James G. King, Henry Markram, and Daniel Keller.

Data Availability:

Archive.zip: Contains the results of the three simulations presented in the paper. For each simulation, there are .h5files that include the average concentrations and voltages of the neurons in the circuit.

Data.zip: Contains the datasets derived from the simulation results used in the paper's figures.

These datasets have been used in the following repository:https://github.com/BlueBrain/Molsys-MetabolicModel/tree/main/Multiscale_electrometabolic_ratneocortex

Acknowledgments:

This study was supported by funding to the Blue Brain Project, a research center of the Ecole Polytechnique Fédérale de Lausanne (EPFL), from the Swiss government’s ETH Board of the Swiss Federal Institutes of Technology.