Stereoselective Synthesis of 3-Aminoindan-1-ones and Subsequent Incorporation into HIV-1 Protease Inhibitors
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https://figshare.com/articles/dataset/Stereoselective_Synthesis_of_3_Aminoindan_1_ones_and_Subsequent_Incorporation_into_HIV_1_Protease_Inhibitors/3239947
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资源简介：
A new method for the stereoselective synthesis of 3-aminoindan-1-ones from triflates of salicylic sulfinyl imines and
ethylene glycol vinyl ether has been developed. The reaction
sequence starts with a regioselective Heck reaction followed
by stereoselective Lewis acid mediated annulation. Acidic
cleavage of the sulfinamides produced pure (R)- and (S)-3-aminoindan-1-ones, which were successfully isolated and
incorporated into active HIV-1 protease inhibitors.
创建时间：
2016-05-05
