Mesenchymal subtypes of hepatocellular carcinoma. Mesenchymal subtypes of hepatocellular carcinoma

Clinical heterogeneity of hepatocellular carcinoma (HCC) reflected in unequal outcome of treatment is poorly defined in molecular level, and molecular subtypes and their associated biomarkers have not been established to improve prognostification and treatment of HCC. Using microarray technologies, we analyzed gene expression profiling data from HCC patients, uncovered mesenchymal subtype, and identified gene expression signature associated with mesenchymal phenotype of HCC. Overall design: We generated gene expression data from tumors of 110 HCC patients who underwent surgical resection as primary treatment