Clinical trials conducted for the FDA approval of ADHD drugs in children.

aAssumed equal distribution of randomized participants between the two study arms.bNot all unique patients as some participants from efficacy trial subsequently enrolled in safety trial.cMethylin was a new formulation of FDA-approved methylphenidate.dFDA approval package includes information on pre-clinical trials only and there is no mention of the conduct of clinical trials.eThe FDA approval package included clinical trials of Dexedrine and Biphetamine for the treatment of obesity in adults, but no clinical trials assessing their use for the treatment of ADHD were identified.fAdderall was originally approved in 1960 as an anorectic under the brand name Obetrol, but no clinical trials assessing their use for the treatment of ADHD were identified.