Crystal structure of CDK2-cyclin E1 bound by compound 30

Crystal structure of CDK2-cyclin E1 bound by compound 30 Descriptor: 2-[(2~{S})-1-[9-ethyl-6-[(2-methyl-5-methylsulfonyl-pyrazol-3-yl)amino]purin-2-yl]-4,4-bis(fluoranyl)pyrrolidin-2-yl]propan-2-ol, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 Authors: Collie, G.W. Deposit date: 2024-09-05 Release date: 2025-09-10 Last modified: 2025-09-24 Method: X-RAY DIFFRACTION (2.158 Å) Cite: Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome. J.Med.Chem., 68, 2025