Miniaturized optically-generated Bessel beam ultrasound for volumetric transcranial brain stimulation

Non-invasive stimulation of small, variably shaped brain sub-regions is crucial for advancing our understanding of brain functions. Current ultrasound neuromodulation faces two significant trade-offs when targeting brain sub-regions: miniaturization versus volumetric control, and spatial resolution versus transcranial capability. Here, we present an optically-generated Bessel beam ultrasound (OBUS) device designed to overcome these limitations. This miniaturized device, measuring 2.33 mm in diameter, delivers a column-shaped field achieving a lateral resolution of 152 μm and an axial resolution of 1.93 mm, enabling targeting of brain sub-regions with an elongated volume of tissue activation. Immunofluorescence imaging of mouse brain slices confirms its ability to stimulate cells at depths up to 2.1 mm. Additionally, OBUS outperforms conventional Gaussian ultrasound in transcranial transmission efficiency and beam shape preservation. Electrophysiological recordings and functional MRI cap..., , , # Data from: Miniaturized optically-generated Bessel beam ultrasound for volumetric transcranial brain stimulation

Dataset DOI: [10.5061/dryad.zgmsbccr0](10.5061/dryad.zgmsbccr0)

## Description of the data and file structure

* Figure 1G includes the peak amplitude data of the acoustic signals acquired. 
* Figure 2B includes the axial profile of the simulated acoustic field.
* Figure 3E.xlsx includes all the persons' coefficients acquired from ImageJ.
* Ultrasound_2.8_MPa.zip, Ultrasound_3.7_MPa, and Ultrasound_4.1_MPa include all the raw electrophysiology data acquired in three mice. 
* Figure 5D includes the average and standard deviation of the BOLD signal for subjects 1 and 2.

### Files and variables

#### File: Figure1G.xlsx

**Description:** Peak-to-peak value of the acoustic signals acquired.

##### Variables

* PDMS ratio, unit: NA.
* Amplitude, unit: mV.

#### File: Figure2B.xlsx

**Description:** The data files contain measurements of ultrasound field characteristics a...,