Lactobacillus rhamnosus GG attenuates NAFLD/NASH progression by modulating Gut Microbiota and Metabolic Pathways

Our research investigates the role of gut microbiota dysbiosis in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), which is an important area in food microbiology focusing on the relationship between microorganisms and host health. The study centers on the role of Lactobacillus rhamnosus GG (LGG) as a probiotic in ameliorating NAFLD and NASH, involving the regulation of gut microbiota by probiotics and their impact on host metabolism and immune responses. This represents a core aspect of probiotic research in food microbiology. The study also highlights that LGG improves lipid metabolism and inflammatory responses by promoting the production of short-chain fatty acids (SCFAs), which involves the influence of microbial metabolites on host health and is a key component of microbial metabolism research in food microbiology. Additionally, we explore the restorative effects of LGG on intestinal barrier function, involving the interaction between microorganisms and intestinal epithelial cells, which is a critical aspect of studying microbe-host interface interactions in food microbiology. In summary, our research delves into the role of microorganisms in liver diseases by examining the effects of probiotics on gut microbiota, microbial metabolites, and intestinal barrier function, aligning with the research scope of food microbiology.