NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice

RNA-seq analysis was performed in samples from WT and NOX4 Knock-out mice after two-thirds Partial Hepatectomy (PH). Transcriptomic analysis through RNA-seq revealed significant changes mainly 24 hours after PH in NOX4-/- mice and support a relevant role for Myc in a node of regulation of proliferation-related genes. Two-thirds Partial Hepatectomy was performed in WT and NOX4 Knock-out mice and samples were collected at different time points after the surgeries. Liver mRNA samples were obtained and RNA-seq was performed.