Global gene expression profiling of mouse soleus hindlimb muscle following gradual exposure to hypoxia. Mus musculus

Young adult C57 mice were exposed to chronic hypoxia for up to 2 weeks. Control mice were maintained under normoxic conditions Overall design: To capture the temporal effect of reduced oxygen tension on gene regulation, we sampled and gene profiled the soleus hindlimb muscle (n=4) at 4 different time-points (day 0, 3, 7 and 14) following initiation of the gradual hypoxic insult (i.e. the O2 level was gradually lowered to 10% over the first week and kept stable during the second week).