ITEDE
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Drug-metabolizing enzymes (DMEs) are critical determinant of drug safety and efficacy, and the interactome of DMEs has attracted extensive attention. There are 3 major interaction types in an interactome: microbiome-DME interaction (MICBIO), xenobiotics-DME interaction (XEOTIC), and host protein-DME interaction (HOSPPI). The interaction data of each type are essential for drug metabolism, and the collective consideration of multiple types has implication for the future practice of precision medicine. However, no database was designed to systematically provide the data of all types of DME interactions. Here, a database of the Interactome of Drug-Metabolizing Enzymes (INTEDE) was therefore constructed to offer these interaction data. First, 1,047 unique DMEs (448 host and 599 microbial) were confirmed, for the first time, using their metabolizing drugs. Second, for these newly confirmed DMEs, all types of their interactions (3,359 MICBIOs between 225 microbial species and 185 DMEs; 47,778 XEOTICs between 4,150 xenobiotics and 501 DMEs; 7,849 HOSPPIs between 565 human proteins and 566 DMEs) were comprehensively collected and then provided, which enabled the crosstalk analysis among multiple types. Because of the huge amount of accumulated data, the INTEDE made it possible to generalize key features for revealing disease etiology and optimizing clinical treatment. INTEDE is freely accessible at: https://idrblab.org/intede/.
药物代谢酶（Drug-metabolizing Enzymes，DMEs）是决定药物安全性与有效性的关键因素，其相互作用组（interactome）已受到广泛关注。相互作用组主要包含三类相互作用类型：微生物组-药物代谢酶相互作用（MICBIO）、外源性物质-药物代谢酶相互作用（XEOTIC）以及宿主蛋白-药物代谢酶相互作用（HOSPPI）。各类相互作用数据对于药物代谢研究均不可或缺，综合考量多种相互作用类型则可为未来精准医学实践提供重要参考。然而，目前尚无数据库能够系统性提供所有类型的药物代谢酶相互作用数据。为此，本研究构建了药物代谢酶相互作用组数据库（Interactome of Drug-Metabolizing Enzymes，INTEDE），以提供上述各类相互作用数据。首先，基于其可代谢的药物底物，本研究首次确认了1047种独特的药物代谢酶，其中宿主来源448种、微生物来源599种。其次，针对上述新确认的药物代谢酶，本研究全面收集并整合了其所有类型的相互作用数据：225种微生物与185种药物代谢酶之间的3359条MICBIO数据、4150种外源性物质与501种药物代谢酶之间的47778条XEOTIC数据，以及565种人类蛋白与566种药物代谢酶之间的7849条HOSPPI数据，从而支持多类型相互作用的交叉分析。得益于海量积累的交互数据，INTEDE可用于归纳关键特征，以揭示疾病病因并优化临床治疗方案。INTEDE可通过以下网址免费访问：https://idrblab.org/intede/
