JAG2 signaling induces differentiation of CD14+ monocytes into Langerhans Cell Histiocytosis-like cells. JAG2 signaling induces differentiation of CD14+ monocytes into Langerhans Cell Histiocytosis-like cells

This study aims to identify the cell of origin of Langerhans Cell Histiocytosis and the molecular mechanisms of its pathogenesis. Overall design: Primary cells were isolated from peripheral blood (CD14 monocytes, CD1c DCs) and treated with JAG2, IgG or IL4 6 different conditions: CD14 and CD1c treated with IgG, JAG2 or IL4