Human Mfn2 M393I and R400Q induce Drosophila eye abnormalities similar to eye-specific suppression of endogenous Drosophila mitofusin (dMfn).

(A) Bright field microscopy images of adult control (ey-Gal4) and Drosophila mitofusin (dMfn) deficient (dMfn/MARF RNAi) eyes. dMfn2-deficient eyes are characteristically smaller and exhibit ommatidial disorganization and dysmorphology (white arrow). (B-D) Representative images and mean eye size data for Drosophila with eye-specific expression of wild-type or mutant human Mfn2, alone (C) or in the presence of dMfn RNAi (D) Eye size data are presented as mean ± SEM. Asterisk = p